Endocrine Abstracts

Adrenal myelolipoma is rare benign tumor composed of mature adipose cells and hematopoietic elements. Their mostly small size (<5 cm), unilateral site, and clinical quiescence is accountable for predominantly incidental disclosure. We report a case of 54-year-old man complaining of gradually aggravating pain in right hemiabdomen in whom abdominal CT revealed bilateral and giant adrenal masses composed of predominately adipose tissue with interspersed areas of solid parts d...

Septo-optic dysplasia (SOD), previously termed De Morsier’s syndrome, is a rare developmental disorder of midline brain structures characterized by optic nerve hypoplasia (ONH), midline neuroradiological abnormalities, and pituitary–hypothalamic dysfunction such as GH deficiency. The phenotype is highly variable and the clinical presentation may be mild or extremely severe. It is an infrequent disease and its causation is most presumably multifactorial, involving env...

Nearly one third of women diagnosed with invasive breast cancer are younger than 50 years with regular menstrual cycles. 60% of these tumors express estrogene and progesterone receptors. Common treatment procedure is surgery followed by chemotherapy, radiotherapy and hormone therapy. Often in younger patients chemotherapy causes permanent amenorrhoea. In case that menses afterwards occurs ovarial suppression is needed, mostly by goserelin, LH-RH agonist. The principle of thera...

Intrathyroidally located parathyroid carcinoma is extremely rare cause of primary hyperparathyroidism. Multifocal papillary and follicular thyroid carcinomas are rather common.We report a case of 40-year old man presenting with substantial weight loss, anemia and multiple osteolytic lesions of both tibias. Peak serum calcium level was 5.0 mmol/l, parathyroid hormone (PTH) level was 989 pg/ml. Left thyroid lobe was firm and enlarged. Routine percutaneous ...

A 74-year-old female patient was admitted to Department of Neurology due to bilateral ptosis and diplopia she suddenly felt 3 weeks prior to admission. She also complained of weakness, dizziness and swallow disability. Her medical history revealed hypertension and minor depressive disorder. Body mass index was 32 kg/m2. Electrocardiogram, chest X-ray and complete laboratory findings were normal, except elevated TSH, so levothyroxin was included in therapy. She had p...

Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The aims of this study were to assess a possible hypothalamo-pituitary-adrenal (HPA) axis dysfunction in population of alcoholics, using dexamethasone suppression test (DST). The study was approved by local Ethical Committee. The serum and urinary cortisol were compared between the groups of 89 male patients (64.5% depressive and 35.5% nondepressive alcoho...

We studied levels of T3, T4, FT3, FT4, rT3 and TSH concentrations in serum and FT3, FT4, rT3 and TSH concentrations in cerebrospinal fluid (CSF) in 10 patients with brain tumor and 20 patients with acute stroke and compared them to 7 patients in control group (further clinical evaluation in control group did not show brain lesions). All patients were euthyroid. The study was approved by loc...

Bilateral adrenalectomy usually results in lifelong primary adrenal insufficiency. Evidence exists that up to 34% of patients with Cushing’s disease (CD) have some degree of endogenous cortisol secretion after bilateral adrenalectomy due to ACTH driven hyperplasia of residual cortical tissue. We present a case of a patient with atypical corticotropinoma/carcinoma and recurrence of CD after bilateral adrenalectomy.A 59-year-old man presented with Cus...

Studies that consolidate the results of medicamentous and surgical treatment of pituitary adenomas are scarce. Pure endoscopic endonasal transsphenoidal surgery is rather new technique.The aim of this study is to report on early postoperative outcome of pure endoscopic endonasal transsphenoidal surgery and to present the results of multimodal treatment in patients with postsurgical failure.We reviewed 117 consecutive patients who u...

Introduction: Falsely elevated serum chromogranin A (CgA) is associated with the use of proton pump inhibitors, the presence of renal impairment and systemic inflammation. We aimed to investigate which laboratory parameters are independently associated with increased CgA and to develop a nomogram, in order to improve the diagnostic accuracy of CgA in detecting patients with neuroendocrine tumors (NET).Methods: Our retrospective study included 155 subject...